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- Molecular mechanisms of cell adhesion in regular and reworked cells.
- To investigate the cellular and molecular mechanisms that underlie these modifications, we now have established conditions under which E-to-A conversion happens in cultured explants of central nervous system tissues.
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The price of E-to-A conversion and the proportions of the completely different A types synthesized in vitro have been similar to these noticed for the tissues in vivo at comparable instances. These outcomes suggest that the publish translational processing in vitro was similar to that in vivo. The information had been in maintaining with the chance that the increase in synthesis of A types occurred both in cells that had previously synthesized E varieties or in a distinct population of cells that already synthesized A forms. In pulse-chase experiments, the E form of N-CAM that was synthesized during the first day after explantation persisted as E form for several days, at occasions when newly synthesized N-CAM was predominantly in A forms.
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Data that’s available contains informati… The neural cell adhesion molecule (N-CAM) inhibits proliferation in main cultures of rat astrocytes. The mechanism of binding of neural cell adhesion molecules.
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